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[P2–332]: RECOVERY OF CEREBRAL TISSUE STRUCTURES AND MITOCHONDRIA APPARATUS BY MEANS OF TRANSCATHETER LASER REVASCULARIZATION DURING AD
Author(s) -
Maksimovich Ivan V.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.986
Subject(s) - dementia , atrophy , medicine , clinical dementia rating , cardiology , vascular dementia , pathology , disease
Background: The recovery of cerebral blood supply, microcirculation, and tissue and cell structures are up-to-date problems in development of new AD treatments. Here presented are the results of AD treatment based on angiogenesis stimulation, recovery of microcirculatory bed, and tissue and cell brain structures by means of transcatheter impact of low-energy laser.Methods:From 93 patients with AD 48 patients aged 34-79 (average 65) were singled out, among which: Group (TDR-0) 4 (8.33%) pre-clinical AD stage without any particular cognitive impairment and dementia manifestations, having 2 or more direct relatives with AD; Group (TDR-1) 16 (33.33%) AD history up to 2 years, mild dementia, mild cognitive impairment and mild manifestations of the disease (corresponds to CDR-1); Group (TDR-2) 21 (43.75%) AD history up to 6 years, moderate dementia, persistent cognitive impairment and more severe manifestations of the disease (corresponds to CDR-2); Group (TDR-3) 7 (14.58%) AD history of 7-12 years, severe dementia, severe cognitive impairment and late stages of the disease (corresponds to CDR-3). The examination included MMSE, CDR, TDR assessment, cerebral CT, MRI (with temporal lobes atrophy degree calculation and AD stages determination by «Tomography Dementia Rating scale» -TDR), SG, REG, and cerebral MUGA. Basic cerebral changes at AD were identified: temporal lobes atrophy, along with capillary blood flow reduction in the temporal and fronto-parietal regions, with simultaneous multiple arteriovenous shunts in the