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[P2–331]: VITAMIN D SUPPLEMENTATION MAY PROTECT AGAINST OXIDATIVE STRESS IN A VITAMIN D DEFICIENT DOUBLE‐TRANSGENIC MOUSE MODEL OF ALZHEIMER's DISEASE
Author(s) -
Wong Dickson,
Bellyou Miranda,
Beauchet Olivier,
MonteroOdasso Manuel,
Annweiler Cedric,
Bartha Robert
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.985
Subject(s) - memantine , oxidative stress , neuroprotection , endocrinology , medicine , vitamin d and neurology , nmda receptor , genetically modified mouse , antioxidant , pharmacology , chemistry , receptor , transgene , biochemistry , gene
to the frontal predominance of MBs in PCA in one prior report.Although the significance of MBs in AD are not fully understood, differences in prevalence and location of MBs for patients presenting with focal cortical syndromes associated with AD pathology, such as PCA, deserve further exploration in a larger cohort. References: 1.Whitwell JL, et al. Microbleeds in atypical presentations of Alzheimer’s disease: a comparison to dementia of the Alzheimer’s type. JAlzheimers Dis. 2015;45(4):1109-17. 2. Sepehry AA, et al. Prevalence of Brain Microbleeds in Alzheimer Disease: A Systematic Review and Meta-Analysis on the Influence of Neuroimaging Techniques. AJNR Am J Neuroradiol. 2016;37(2):215-22. 3. Tang-Wai DF, et al. Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology. 2004;63(7):1168-74.