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[P2–319]: AMNESTIC MILD COGNITIVE IMPAIRMENT: RISK FACTORS FOR CONVERSION TO DEMENTIA IN A SAMPLE OF BRAZILIAN ELDERLIES WITH LOW EDUCATIONAL LEVEL
Author(s) -
Bicalho Maria Aparecida,
Cintra Marco Túlio,
Ribeiro da Silva Andrea,
Correa Pedro Neiva,
Lage Ariane,
Ávila Rafaela,
Nunes de Moraes Edgar
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.973
Subject(s) - dementia , medicine , logistic regression , population , cognition , cohort , gerontology , demography , psychology , disease , psychiatry , environmental health , sociology
Samsung Medical Center (SMC) and 50% of 233 aMCI patients from multi-center hospital based prospective cohort the Clinical Research Center for Dementia of South Korea (CREDOS) were used as training data set, and the remaining was used as validation data set. On logistic regression model, late, both, multiple domain aMCI and age were significantly associated with AD conversion within 3 years. A nomogram incorporating these clinical variables was constructed on the training data set and validated on the validation data set. This nomogram showed fair prediction performance (c-statistics 0.7) with R-squared >0.3. Conclusions: This study showed that several neuropsychological profiles of aMCI are significantly associated with imminent AD conversion and a nomogram incorporating these clinical subtypes is simple and useful to help to predict disease progression.