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[P2–302]: ONE‐YEAR INTERVAL MONTREAL COGNITIVE ASSESSMENT AND RISK OF PERITONITIS IN SELF‐CARE PERITONEAL DIALYSIS PATIENTS
Author(s) -
Shea Yat Fung,
Connie Lee Mi Suen,
Maggie Mok Ming Yee,
Lam Man Fai,
Chu Leung Wing,
Felix Chan Hon Wai,
Chan TakMao
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.955
Subject(s) - medicine , peritoneal dialysis , hazard ratio , peritonitis , proportional hazards model , montreal cognitive assessment , risk factor , cohort , prospective cohort study , confidence interval , surgery , cognitive impairment , disease
Background: Cognitive impairment (CI) may have a negative impact on the outcome of patients on peritoneal dialysis (PD), especially in the risk of peritonitis. Methods:This was a two-year prospective single-centre cohort study. Hong Kong Montreal Cognitive Assessment (HK-MoCA) was performed in patients newly started on PD between July 2011 and August 2014, and repeated one year later. Demographics and clinical data including co-morbidities, medications, peritonitis were collected. CI was determined by locally defined HK-MoCA cut-off. Patients were classified as “cognitively impaired” (Ci) if they remained CI or became CI at one-year; remaining patients were classified as “cognitively preserved” (Cp). Results:104 patients were included. An age older than 65 years old was an independent risk factor for CI (OR 3.37, 95% CI 1.31-8.65, p1⁄40.01). Ci had a higher PD peritonitis rates (1 episode per 22 patient months vs. 1 episode per 54 patient months, p1⁄40.01) and longer median length of admissions (11 days (IQR 6-25) vs. 0 day (IQR 0-6), p<0.001) than Cp after exclusion of helpers. Baseline serum albumin level and classification as Ci were independent factors predicting PD related peritonitis (hazard ratios 0.90 (95% CI 0.82-0.98) p1⁄40.02, 2.48 (95% CI 1.12-5.49) p1⁄40.03 respectively) using cox regression model. Classification as Ci was associated with shorter peritonitis free survival according to Kaplan Meier curve (p1⁄40.01). Conclusions:Age is an independent risk factor for CI in PD patients. CI increases the risk of PD-related peritonitis.