[P2–302]: ONE‐YEAR INTERVAL MONTREAL COGNITIVE ASSESSMENT AND RISK OF PERITONITIS IN SELF‐CARE PERITONEAL DIALYSIS PATIENTS

Background: Cognitive impairment (CI) may have a negative impact on the outcome of patients on peritoneal dialysis (PD), especially in the risk of peritonitis. Methods:This was a two-year prospective single-centre cohort study. Hong Kong Montreal Cognitive Assessment (HK-MoCA) was performed in patients newly started on PD between July 2011 and August 2014, and repeated one year later. Demographics and clinical data including co-morbidities, medications, peritonitis were collected. CI was determined by locally defined HK-MoCA cut-off. Patients were classified as “cognitively impaired” (Ci) if they remained CI or became CI at one-year; remaining patients were classified as “cognitively preserved” (Cp). Results:104 patients were included. An age older than 65 years old was an independent risk factor for CI (OR 3.37, 95% CI 1.31-8.65, p1⁄40.01). Ci had a higher PD peritonitis rates (1 episode per 22 patient months vs. 1 episode per 54 patient months, p1⁄40.01) and longer median length of admissions (11 days (IQR 6-25) vs. 0 day (IQR 0-6), p<0.001) than Cp after exclusion of helpers. Baseline serum albumin level and classification as Ci were independent factors predicting PD related peritonitis (hazard ratios 0.90 (95% CI 0.82-0.98) p1⁄40.02, 2.48 (95% CI 1.12-5.49) p1⁄40.03 respectively) using cox regression model. Classification as Ci was associated with shorter peritonitis free survival according to Kaplan Meier curve (p1⁄40.01). Conclusions:Age is an independent risk factor for CI in PD patients. CI increases the risk of PD-related peritonitis.