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[P2–300]: CORTICAL THICKNESS OF MEDIAL PERIRHINAL CORTEX PREDICTS VERBAL SEMANTIC FLUENCY PERFORMANCE FOR LIVING THINGS
Author(s) -
Krumm Sabine,
Hermann Rebecca,
Oeksuez Fatma,
Monsch Andreas U.,
Stippich Christoph,
Kressig Reto W.,
Taylor Kirsten I.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.953
Subject(s) - perirhinal cortex , entorhinal cortex , psychology , verbal fluency test , audiology , cortex (anatomy) , atrophy , parahippocampal gyrus , semantic memory , neuroscience , temporal lobe , medicine , hippocampus , neuropsychology , cognition , pathology , recognition memory , epilepsy
for CA2/3 where it was trending (p1⁄4.075). Increased EC Tau was also associated with decreased memory awareness r1⁄40.5, p<.001. Of the HCsf only the subiculum (r1⁄40.4, p<.001) and CA1 (r1⁄40.3, p1⁄4.004) demonstrated a significant association, such that lower volume was associated with decreased memory awareness. Last, subiculum volume was found to partially mediate the relationship between EC Tau and memory awareness (bias-bootstrapping 95% BCI, [-0.63, -0.02]), Sobel test t1⁄4-2.1, p1⁄4.036 (Figure). None of the other HCsf showed a significant mediation effect. Conclusions:These results suggest strong links among EC tau burden, HCsf subfields and memory awareness, and highlight the involvement of MTL regions in anosognosia. Furthermore, decreased memory awareness may be caused by tau-induced subiculum volume loss in a group of individuals with varying degrees of memory impairment. Future work should examine the interplay between amyloid pathology and these MTL neurodegenerative measures for memory awareness.