Premium
[P2–299]: THALAMIC CONNECTIVITY CONTRIBUTES TO EPISODIC MEMORY IN MILD COGNITIVE IMPAIRMENT
Author(s) -
Berlot Rok,
Pileckyte Indre,
Brezovar Simon,
Koritnik Blaž,
Pirtošek Zvezdan
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.952
Subject(s) - episodic memory , fractional anisotropy , hippocampus , thalamus , neuroscience , psychology , hippocampal formation , diffusion mri , cognition , clustering coefficient , cluster analysis , magnetic resonance imaging , medicine , computer science , artificial intelligence , radiology
for CA2/3 where it was trending (p1⁄4.075). Increased EC Tau was also associated with decreased memory awareness r1⁄40.5, p<.001. Of the HCsf only the subiculum (r1⁄40.4, p<.001) and CA1 (r1⁄40.3, p1⁄4.004) demonstrated a significant association, such that lower volume was associated with decreased memory awareness. Last, subiculum volume was found to partially mediate the relationship between EC Tau and memory awareness (bias-bootstrapping 95% BCI, [-0.63, -0.02]), Sobel test t1⁄4-2.1, p1⁄4.036 (Figure). None of the other HCsf showed a significant mediation effect. Conclusions:These results suggest strong links among EC tau burden, HCsf subfields and memory awareness, and highlight the involvement of MTL regions in anosognosia. Furthermore, decreased memory awareness may be caused by tau-induced subiculum volume loss in a group of individuals with varying degrees of memory impairment. Future work should examine the interplay between amyloid pathology and these MTL neurodegenerative measures for memory awareness.