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[P2–297]: THE CORRELATION OF SENSE OF LOCATION AND REAL‐WORLD NAVIGATION ABILITIES: A PRELIMINARY REPORT
Author(s) -
Pai MingChyi,
Jan ShauShiun,
Lin ChunYu,
Chang LingHui,
Cheng YungHsiang
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.950
Subject(s) - neuropsychology , test (biology) , psychology , cognitive impairment , cognition , set (abstract data type) , gerontology , medicine , audiology , psychiatry , computer science , biology , programming language , paleontology
Background:Spatial navigation impairment (SNI) frequently occurs in people with Alzheimer’s disease (AD), even in the very early stage of it and when the people with AD still residing in the community. The aim of this study was to predict SNI in a group of people with very mild AD by a device to assess sense of location (SoL). Methods: The neuropsychological tests included Mini-mental State Examinaiton (MMSE), Cognitive Abilities Screening Instrument (CASI), and Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). The real-world navigation abilities were assessed by the Questionnaire of Everyday Navigational Ability (QuENA). The history of getting lost events was assessed by the QuENA and obtained from reliable family members, based on which the participants were categorized to frequent way losers (WL) and getting lost resistant (GR, never been lost). The participants were instructed to point their current location on a tablet PC at five test points when they were walking along a route of 660 meters (including forward and backward paths). The SoL was determined by the hit rate of location within pre-set linear deviation of distance. Two independent raters scored the performance of each participants on the SoL. Results: 32 AD participants (15 males) completed the study. Among them, 19 were WL (age 75.366.8 years, education 7.263.4 years, MMSE 20.263.5, CASI 71.5611.7, CDR 0.760.3) and 13 GR (age 72.468.7 years, education 9.363.6 years, MMSE 22.965.4, CASI 78.3613.1, CDR 0.660.2). The age, education, MMSE, CASI and CDR showed no difference between the two groups. The total QuENA score was 11.567.4 for WL and 7.063.5 for GR (p1⁄40.029). The WL showed more linear deviation at the P5 on the backward path (p1⁄40.044), while the other parameters, including SoL, linear deviation, and point-to-start test, showed no difference between the WL and the GR groups. Conclusions: More participants and more subgroups (subtypes or variants) are needed to verify the the role of SoL in SNI in AD. The underlying mechanisms for human spatial navigation are complex. More efforts must be put before the real causes are clearly known. A) Schematic representation of the direct effect. B) The subiculum partially mediates the relationship between entorhinal Tau binding and memory awareness. Standardized regression coefficients arc presented: a1⁄4the association between EC Tau and subiculum volume, b1⁄4the association between P2-298 ASSOCIATIONS BETWEEN MEASURES OF