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[P2–292]: A STUDY ON THE RELATIONSHIP BETWEEN COGNITIVE FUNCTION AND ELDERLY PATIENTS WITH PERIODONTITIS AT QINGHAI‐TIBETIAN PLATEAU
Author(s) -
Wang Yajie,
Zhu Aiqin,
Du Can
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.945
Subject(s) - medicine , periodontitis , periodontal examination , cognition , dentistry , quadrant (abdomen) , physical examination , clinical attachment loss , mini–mental state examination , cognitive impairment , disease , psychiatry , surgery
but not in multivariate analysis, with hazard ratios of 1.96 and 2.25, respectively. Depression (vs. no depression), “depression without apathy” (vs. “no depression or apathy”) did not significantly increase the risk of conversion. When the cutoff was raised to F*S>1⁄44 (a threshold of clinically meaningful symptom), baseline depression (vs. no depression) and “depression without apathy” (vs. “no depression or apathy”) increased the risk of progression to dementia in multivariate analysis, with hazard ratios of 3.46 and 4.30, respectively. Persistence of apathy significantly increased the risk of progression to dementia in univariate analysis (HR: 3.34; 95% CI: 1.46, 7.63), but not in multivariate analysis. The scarce case number limited similar analysis for persistence of depression. Conclusions:For patients with MCI, the presence of clinically meaningful depression may be a good predictor of progression to dementia. Apathy alone or persistence of apathy for 6monthsmay also be potential predictors. Large-scale studies can help to validate these findings.