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[P2–281]: CAREGIVER BURDEN IN FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS: PRELIMINARY DATA IN THE LEFFTDS COHORT
Author(s) -
Hughes Samantha R.,
Boeve Brad F.,
Rosen Howard J.,
Boxer Adam L.,
Calvert Kendrick J.,
Dheel Christina,
Dickerson Bradford C.,
Fields Julie A.,
Gavrilova Ralitza H.,
Ghoshal Nupur,
Goldman Jill,
GraffRadford Neill R.,
Grossman Murray,
Heuer Hilary,
Robin Hsiung GingYuek,
Huey Edward D.,
Irwin David J.,
Knopman David S.,
Kornak John,
Kraft Ruth A.,
Kramer Joel H.,
Mackenzie Ian R.,
Miller Bruce L.,
Miller Matt R.,
Rankin Katherine,
Syrjanen Jeremy,
Weintraub Sandra,
Wszolek Zbigniew
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.934
Subject(s) - frontotemporal dementia , clinical dementia rating , medicine , cohort , dementia , wilcoxon signed rank test , caregiver burden , mann–whitney u test , disease
Background: There is a relationship between presbycusis and cognitive impairment. To study the relation between cognitive impairment and auditory sensorial input we performed Auditory Brainstem Response (ABR), which provides information on the peripheral hearing status through amplitude and time of response from auditory nerve (wave I) to the inferior colliculus (wave V) and a cognitive evaluation, with emphasis on auditory verbal working memory (WM). Objective: To determine if the electrophysiological response of the Peripheral auditory pathway is associated with the performance in WM tests. Methods: Participants (N 1⁄4 55): subjects over 65 years, without dementia. They were evaluated with a comprehensive battery of neuropsychological test including visual and verbal WM, and a complete auditory evaluation including ABR and Pure Tone Audiometry (PTA). Subject included with normal hearing (PTA <20dB) or with mild (PTA 20-40dB) to moderate (PTA >40dB) presbycusis. The auditory material for testing WM was created from the Speech Perception in Noise Test (SPIN), including phrases with two variables: background noise (on /off) and predictability of the last word in relation to the content of the sentence. Results: Performance on SPIN was better with no background noise (p <0.01) and with greater predictability (p <0.01). As a whole, SPIN is associated with the PTA (p <0.001). WM task was associated with other cognitive test: MMSE (p <0.05), indirect span of the Corsi Test (p<0.05), indirect digit span (p <0.05) and the Grobber & Buschke test (P <0.05). Using Median Regression and controlling for covariates, the WM score was negatively associated