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[P2–271]: TOWARD BETTER CONDUCT OF MULTINATIONAL CLINICAL TRIALS: COMPARISON OF CLINICAL ASSESSMENT SCALES BY REGIONS (NORTH AMERICA AND JAPAN)
Author(s) -
Kikuchi Masashi,
Matsumaru Naoki,
Tsukamoto Katsura
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.924
Subject(s) - clinical trial , population , multinational corporation , psychology , cognitive assessment system , medicine , clinical psychology , baseline (sea) , disease , cognitive impairment , environmental health , biology , political science , law , fishery
data were obtained from the electronic medical record for all patients with a clinician’s diagnosis of Alzheimer’s disease (331.0) and Dementia with Lewy Bodies (331.82) at the UAB Memory Disorders Clinic from 4/30/2012 to 4/30/2015. ABCs and RCS data were available on 76 patients diagnosed with Alzheimer’s disease (mean age 75) and 34 patients diagnosed with Dementia with Lewy Bodies (mean age 72). The correlation between the scores on both tests was calculated. Additionally, mean ABCs scores were compared by Kruskal Wallis tests between the two groups. Results: ABCs and RCS scores showed a moderate strength correlation across all patients (Spearman Correlation Coefficient1⁄40.69). This correlation persists for each diagnosis individually, r1⁄40.68 for AD and r1⁄40.71 for DLB. Mean ABCs scores were 17.0 for subjects with AD and 20.3 for subjects with DLB (c21⁄46.1; P1⁄40.013). Mean RCS scores were 5.43 for AD and 5.76 for DLB; no statistical difference was observed between the 2 diagnoses. Conclusions: The predicted relationship between the performance on the ABCs and RCS was established. The RCS did not differentiate between groups. Mean ABCs scores were significantly higher among DLB patients suggesting the ABCs may be more sensitive to AD than DLB. Since the scoring distribution of the ABCs is similar to that of the MiniMental State Exam, our findings are consistent with prior observations that the Montreal Cognitive Assessment is better suited for identifying cognitive impairment associated with parkinsonism. These findings further support the utility of the ABCs for assessing cognitive impairment for common diagnoses among patients attending a Memory Disorders Clinic for dementia-related conditions.