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[P2–267]: IN VIVO TAU DEPOSITION REFLECTS NEUROPSYCHIATRIC SYMPTOMS IN COGNITIVELY IMPAIRED PATIENTS
Author(s) -
You Hyun Ju,
Seo Seongho,
Lee SangYoon,
Jeong Hye Jin,
Park Kee Hyung,
Yeon Byeong Kil,
Okamura Nobuyuki,
Ido Tatsuo,
Na Duk L.,
Noh Young
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.920
Subject(s) - precuneus , psychology , posterior cingulate , temporal cortex , inferior parietal lobule , dementia , neuroscience , medicine , audiology , cortex (anatomy) , cognition , disease
Methods:A convenience sample of 88 AD patients was graduated in very mild to mild to moderate severity using the clinical dementia rating (CDR) (CDR 0,5, n1⁄421); (CDR 1 1⁄444 & CDR 2 n1⁄4 23). They were assessed with measures of global cognition, executive functions, episodic memory; NPS, apathy, depression and functionality (technology-activities of daily living questionnaire (T-ADLQ)). Lineal regression models were done to assess the better predictors for functional impairment in the global group and in the mild and moderate severity patients separately. Results:Functional impairment was 35618 % in the total sample, increasing it proportion according to disease severity (CDR 0,5&11⁄429% CDR2&31⁄446%). At least one behavioral symptom was present in 87% of AD patients, depressive symptoms were present in about half of the patients. Apathy (defined as AES-i >41) was present in 44 % of AD patients. Significant predictors of global functional impairment were education, NPS, global cognition and apathy; in mild AD patient’s apathy was the best predictor. Conclusions:Apathy alone explained one third of functional impairment in AD patients, been especially important in the mild severity group, it was even more relevant than measures of episodic memory, executive functions or depression. These results remark the importance of apathy evaluation to fully understand AD patient’s behavior. Funded by FONDECYT 1140423, REDES 150134, Proyecto Anillo ACT1403.