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[P2–240]: SALIVARY BIOMARKERS FOR THE DETECTION OF ALZHEIMER'S DISEASE
Author(s) -
Santos Gustavo AA.,
Paulino Niraldo,
Pardi Paulo Celso
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.892
Subject(s) - saliva , mann–whitney u test , medicine , disease , dementia , alzheimer's disease , gastroenterology , pathology
Al) were measured by flame or graphite furnace atomic absorption spectrometry. SOD activity was measured spectrophotometrically. Results:We have observed that, compared to controls, K and Fe levels were significantly increased in the CSF of AD individuals, while the concentration of Zn and Al were decreased. Further, we observed that total SOD activity was elevated CSF from AD individuals. Conclusions: We have demonstrated the existence of disturbances in the concentrations of K, Fe and Zn, total protein and SOD activity in AD subjects, compared to controls. Therefore ionic markers and their relationship with classical and oxidative stress biomarkers could provide new diagnostic tools for AD.