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[P2–238]: ANALYTICAL PERFORMANCE CHARACTERISTICS OF A PROTOTYPE IMMUNOASSAY FOR QUANTIFICATION OF ALPHA‐SYNUCLEIN IN HUMAN CEREBROSPINAL FLUID
Author(s) -
Chassaing Emeric,
Vergnaud Philippe,
Schubert Tanja,
Vanderstichele Hugo Marcel,
Stoops Erik,
BodnarWachtel Mélanie
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.890
Subject(s) - cerebrospinal fluid , synucleinopathies , dementia with lewy bodies , immunoassay , serial dilution , chemistry , chromatography , medicine , pathology , parkinson's disease , antibody , biomedical engineering , dementia , alpha synuclein , disease , immunology , alternative medicine
α-Synuclein is a pre-synaptic protein whose aggregation is the main characteristic of a subgroup of neurodegenerative disorders called α-synucleinopathies, including but not limited to Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). CFS α-Synuclein levels reflect the presence of Lewy bodies in the brain and have been shown to be decreased in PD and DLB patients as compared to healthy aging controls. Robust assays with good lot-to-lot consistency are required for integration into clinical trials. The data presented in this poster documents the analytical performance characteristics of a novel colorimetric ELISA for αSynuclein measurement in biological fluids (focus: CSF). INTRODUCTION