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[P2–232]: MICROPARTICLES DERIVED FROM TISSUE FACTOR, LEUKOCYTE, ENDOTHELIUM AND NEURON ARE ASSOCIATED WITH ALZHEIMER's DISEASE
Author(s) -
Magalhaes Carolina Antunes,
Carvalho Maria das Graças,
Mello Gomide Loures Cristina,
Chaves Amanda Caroline,
Cintra Marco Túlio,
Bicalho Maria Aparecida,
Sousa Lirlandia Pires,
Fraga Vanessa Gomes,
Caramelli Paulo,
Campos Fernanda Freire,
Gomes Borges Karina Braga
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.884
Subject(s) - chemokine , endothelium , population , flow cytometry , interquartile range , inflammation , medicine , platelet , immunology , pathology , environmental health
panel of rat (APPsi) and mouse (Tg4-42) biofluids and tissues. This give further help to understand the devastating neurodegenerative disease, related complex biochemical pathways and pathophysiological processes of AD.Conclusions:UsingNMR-basedmetabolic phenotyping we defined a quantitative readout of transgenic animal models in the form of a biomarker panel. These biomarkers not only contribute to the understanding of this devastating neurodegenerative disease and the related pathophysiological processes on a systemic level, but set the base for a wide range of biomedical applications. Our approach can be easily extended to other tissues, matrices, or disease models and translated across species since metabolic pathways are conserved through evolution, and are essentially similar in rodents and humans.