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[P2–225]: UTILITY OF EVENT‐RELATED POTENTIALS IN A MEMORY DISORDERS CLINIC
Author(s) -
Budson Andrew,
Turk Katherine,
Suh Cheongmin,
Uppal Prayerna
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.877
Subject(s) - event related potential , audiology , dementia , electroencephalography , clinical dementia rating , neuropsychology , oddball paradigm , neuroimaging , psychology , cognition , medicine , disease , cognitive impairment , neuroscience
Event related potentials (ERPs) are quantitative EEG-derived waveforms time-locked to stimuli that represent cognitive processing. ERPs have the potential to detect subtle cognitive changes in Alzheimer’s disease (AD) by measuring changes in neuroelectrical signals. In particular, the P3b latency is thought to reflect stimulus processing time in relation to memory (Magliero et al., 1984), and has been found to correlate with AD-related cognitive impairment (Cecchi et al., 2015). We examine P3b latencies in relation to medial temporal lobe (MTL) atrophy and performance on MTLrelated neuropsychological measures from a heterogeneous group of memory patients reflective of a typical memory clinic population. Methods Participants consisted of 114 veterans 50-100 years old who were seen in the Memory Disorders Clinic between June 2016 Sept 2017. Pearson’s correlation was made between P3b latencies, cortical and MTL atrophy scores, and the word list learning task from the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) using SPSS. See figure 1 for details. Newcomers to Clinic (MoCA > 10)