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[P2–223]: MARKERS OF CIRCADIAN CLOCK FUNCTION IN ALZHEIMER's DISEASE
Author(s) -
Baird Alison L.,
Anand Sneha N.,
Lovestone Simon
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.875
Subject(s) - circadian rhythm , actigraphy , chronotype , clock , circadian clock , melatonin , medicine , parkinsonism , psychology , disease , physiology , endocrinology
used to investigate short-interval intracortical inhibition (SICI) and facilitation (ICF), long-interval intracortical inhibition (LICI) and short-afferent latency inhibition (SAI) in order to measure the activity of different intracortical circuits, with the application of current reference standards, to differentiate patients with AD from those with FTD and healthy controls (HC). The primary outcome measures were sensitivity and specificity of TMS measures, derived from receiver operator curve analysis.Results:A total of 175 subjects met inclusion criteria.We diagnosed 79ADpatients, 64 FTD patients and 32 HC. We found that while AD patients are characterized by a specific impairment of SAI, FTD show a remarkable dysfunction of SICI-ICF intracortical circuits. Using the best index incorporating these measurements (SICI-ICF / SAI ratio), TMS differentiated FTD from AD with a sensitivity of 91$8% and specificity of 88$6%, AD from HC with a sensitivity of 84$8%, and specificity of 90$6%, and FTD from HC with a sensitivity of 90$2% and specificity of 78$1%. These results were confirmed also in patients with a mild disease. Conclusions:TMS is a non-invasive procedure which reliably distinguishes AD from FTD and HC and, if these findings are replicated in larger studies, could represent a useful adjunctive diagnostic tool to be used in clinical practice.