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[P2–204]: RPT6, 20S α‐6 AND α‐3 PROTEASOME SUBUNIT LEVELS AND ASSOCIATION WITH COGNITIVE DECLINE IN ALZHEIMER's DISEASE AND LEWY BODY DEMENTIAS
Author(s) -
Hortobagyi Tibor,
Alghamdi Amani,
Whitfield David,
Vallortigara Julie,
Howlett David,
Broadstock Martin,
Ballard Clive,
Thomas Alan,
Attems Johannes,
Aarsland Dag,
Francis Paul T.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.855
Subject(s) - dementia with lewy bodies , neuroscience , lewy body , prefrontal cortex , dementia , psychology , pathological , anterior cingulate cortex , hippocampus , cortex (anatomy) , superior frontal gyrus , alzheimer's disease , posterior parietal cortex , angular gyrus , temporal cortex , disease , medicine , cognition
roles and is linked to several cell death-related signaling pathways in ischemia. Methods: DAPK1-NR2B, DAPK1-DANGER, DAPK1-p53, and DAPK1-Tau are currently known pathways in strokeinduced cell death, we block these cascades in an acute treatment to see whether it will reduce damage. Results: Block DAPK1-Tau interaction can effectively reduce neuronal loss. Conclusions:Disrupting DAPK1-relevant cell death pathway could be considered as a promising therapeutic approach in stroke.