[P2–204]: RPT6, 20S α‐6 AND α‐3 PROTEASOME SUBUNIT LEVELS AND ASSOCIATION WITH COGNITIVE DECLINE IN ALZHEIMER's DISEASE AND LEWY BODY DEMENTIAS | Zendy

Hortobagyi Tibor | Zendy; Alghamdi Amani | Zendy; Whitfield David | Zendy; Vallortigara Julie | Zendy; Howlett David | Zendy; Broadstock Martin | Zendy; Ballard Clive | Zendy; Thomas Alan | Zendy; Attems Johannes | Zendy; Aarsland Dag | Zendy; Francis Paul T. | Zendy

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[P2–204]: RPT6, 20S α‐6 AND α‐3 PROTEASOME SUBUNIT LEVELS AND ASSOCIATION WITH COGNITIVE DECLINE IN ALZHEIMER's DISEASE AND LEWY BODY DEMENTIAS

Author(s) -

Hortobagyi Tibor,

Alghamdi Amani,

Whitfield David,

Vallortigara Julie,

Howlett David,

Broadstock Martin,

Ballard Clive,

Thomas Alan,

Attems Johannes,

Aarsland Dag,

Francis Paul T.

Publication year - 2017

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2017.06.855

Subject(s) - dementia with lewy bodies , neuroscience , lewy body , prefrontal cortex , dementia , psychology , pathological , anterior cingulate cortex , hippocampus , cortex (anatomy) , superior frontal gyrus , alzheimer's disease , posterior parietal cortex , angular gyrus , temporal cortex , disease , medicine , cognition

roles and is linked to several cell death-related signaling pathways in ischemia. Methods: DAPK1-NR2B, DAPK1-DANGER, DAPK1-p53, and DAPK1-Tau are currently known pathways in strokeinduced cell death, we block these cascades in an acute treatment to see whether it will reduce damage. Results: Block DAPK1-Tau interaction can effectively reduce neuronal loss. Conclusions:Disrupting DAPK1-relevant cell death pathway could be considered as a promising therapeutic approach in stroke.

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