Premium
[P2–195]: DNA METHYLATION STATUS OF AN EXTENDED APOE LOCUS REGION IN ALZHEIMER'S DISEASE
Author(s) -
Shao Yvonne,
Shaw McKenzie,
Khrestian Maria,
D'Aleo Giana,
Leverenz James B.,
Bekris Lynn M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.846
Subject(s) - apolipoprotein e , dna methylation , epigenetics , methylation , locus (genetics) , biology , genetics , haplotype , disease , gene , allele , gene expression , medicine
CN N1⁄415 MCI Low AD likelihood N1⁄418 MCI SNAP N1⁄414 MCI IAP N1⁄418 MCI High AD likelihood N1⁄427 Ca3, pg/ml 7257 3116 4476 3064 4117 (4553) (2325) (3330) (1881) (2613) SAP, ng/ml 10.7 11.1 8.9 7.5 10.2 (8.8) (17.7) (6.4) (6.2) (23.2) TCC, mAU/ml 36.3 18.8 28.0 31.9 62.4 (35.5) (25.0) (36.0) (32.6) (151.1) HFABP, pg/ml 1033 905 1303 963 1517 (516) (325) (441) (340) (626) Results are mean (SD). CN 1⁄4 cognitive normal; MCI 1⁄4 mild cognitive impairment; SNAP 1⁄4 suspected non-Alzheimer’s disease pathophysiology; IAP 1⁄4 isolated amyloid pathology SAP 1⁄4 serum amyloid P; TCC 1⁄4 C5b-9 terminal complement complex; HFABP 1⁄4 heart-fatty acid binding protein. 1⁄4p<0.05 compared to CN; 1⁄4p<0.05 compared to Low AD likelihood group; 1⁄4p<0.05 compared to SNAP group; 1⁄4p<0.05 compared to IAP group; 1⁄4p<0.05 compared to high AD likelihood group. Poster Presentations: Monday, July 17, 2017 P681