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[P2–176]: EMBELIN MODULATES CENTRAL NEUROTRANSMITTERS AND ATTENUATES STREPTOZOTOCIN INDUCED COGNITIVE IMPAIRMENT AND BIOCHEMICAL ABNORMALITIES IN RATS
Author(s) -
Arora Rimpi,
Deshmukh Rahul
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.827
Subject(s) - streptozotocin , morris water navigation task , neuroprotection , pharmacology , neurochemical , medicine , endocrinology , cognitive deficit , oxidative stress , hippocampus , diabetes mellitus , disease , cognitive impairment
Representative image of western blot analysis of the endogenous ADAM10 protein in SH-SY5Y cells transfected with the negative control or miR-1445p: miR-221, miR-374 mimics. Actin served as an internal control. (B) Quantitative analysis of experiments in (A). Optical densities of ADAM10 bands from five independent experiments were quantified and normalized to the corresponding actin bands. The values were plotted as fold-change with respect to the negative control (miR-144-5p 79.83 6 26.76%; miR-221 57.65 6 14.64%; miR-374 86.80 6 21.31%; * miR221 vs negative control P1⁄40.04). Poster Presentations: Monday, July 17, 2017 P673