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[P2–144]: EXPLORING THE EFFECT OF CENTELLA ASIATICA ON MITOCHONDRIAL BIOGENESIS IN THE MOUSE BRAIN
Author(s) -
Matthews Donald G.,
Gray Nora E.,
Meshul Charles,
Caruso Maya,
Moore Cynthia,
Murchison Charles F.,
Harris Christopher,
Quinn Joseph F.,
Soumyanath Amala
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.794
Subject(s) - centella , hippocampal formation , hippocampus , neurotoxicity , chemistry , microbiology and biotechnology , medicine , pharmacology , endocrinology , biology , toxicity , traditional medicine
assays, 31 showed strong effects in the prevention assay only, and 25 showed stronger effects in the post-catalysis/reversal assay. Of the drugs that were effective in both assays, 38 were also blood-brain-barrier (BBB) permeable. Conclusions: We have selected the 38 BBB permeable candidate drugs capable of both preventing and inhibiting ApoE4-mediated catalysis of Ab oligomer/filament formation for further investigation using both an induced pluripotent stem cell-cerebral organoid model system and TgF344-AD rats to inform future clinical trials. This ApoE-dependent approach to AD drug discovery may identify drugs that are effective independent of, or complementary to, other therapies currently under investigation.