[P2–130]: AR‐A014418, A GSK‐3β INHIBITOR, ATTENUATES ALZHEIMER'S‐ LIKE PATHOLOGY IN HIGH FAT DIET‐INDUCED COGNITIVE DEFICIT IN MICE

the underlying mechanisms involved. Results:Our ChIP analysis and luciferase reporter assays show that palmitate-induced SREBP1 activation directly regulates BACE1 expression at the transcriptional level. Knocking-down or ectopic expression of the dominant negative SREBP1 mutant significantly mitigated the palmitate-induced BACE1 expression and subsequent Ab genesis. Conclusions: Our study elucidates a novel signaling pathway and SREBP1 as a unique downstream effector of palmitate-induced up-regulation in BACE1 expression and subsequent Ab genesis.