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[P2–124]: THE PUERTO RICAN ALZHEIMER DISEASE INITIATIVE (PRADI): INITIAL CLINICAL FINDINGS
Author(s) -
Celis Katrina,
FelicianoAstacio Briseida E.,
Deon Adams Larry,
Bussies Parker,
Sierra Carolina,
HamiltonNelson Kara L.,
Rajabli Farid,
Acosta Heriberto,
Chinea Angel,
McCauley Jacob L.,
Vance Jeffery M.,
Cuccaro Michael L.,
Beecham Gary W.,
PericakVance Margaret A.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.774
Subject(s) - cohort , medicine , gerontology , population , disease , cohort study , demography , pathology , environmental health , sociology
that results in increased amyloid beta levels. Results:We will report our results and discuss how they relate to the relationship between these mutations and both chemokine and amyloid beta levels in mammalian cell lines. Conclusions: This work will allow us to examine the role that amyloid beta plays in the activation of pro-inflammatory responses by the chemokine receptors CCBP2 and CCLR2 and their respective mutants. This work could lead to a means of regulating amyloid beta production and expression which could lead to novel therapeutic solutions.