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[P2–123]: ASSOCIATION OF CHOLESTEROL AND CHOLESTEROL METABOLISM GENES WITH COGNITIVE FUNCTION IN A POPULATION ENRICHED FOR A PARENTAL HISTORY OF ALZHEIMER's DISEASE
Author(s) -
Lazar Karen K.,
Koscik Rebecca L.,
Bautista Leonelo E.,
Sager Mark A.,
Hermann Bruce P.,
Asthana Sanjay,
Johnson Sterling C.,
Carlsson Cynthia M.,
Engelman Corinne D.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.773
Subject(s) - apolipoprotein e , cholesterol , medicine , population , verbal learning , risk factor , endocrinology , psychology , alzheimer's disease , cognition , gerontology , disease , psychiatry , environmental health
that results in increased amyloid beta levels. Results:We will report our results and discuss how they relate to the relationship between these mutations and both chemokine and amyloid beta levels in mammalian cell lines. Conclusions: This work will allow us to examine the role that amyloid beta plays in the activation of pro-inflammatory responses by the chemokine receptors CCBP2 and CCLR2 and their respective mutants. This work could lead to a means of regulating amyloid beta production and expression which could lead to novel therapeutic solutions.