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[P2–121]: CHARACTERIZATION OF MUTANT CHEMOKINE RECEPTORS AND THEIR ROLE IN INFLAMMATION AND ALZHEIMER's DISEASE
Author(s) -
Gonzalez Murcia Josue D.,
Weber K. Scott,
Kauwe John
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.771
Subject(s) - chemokine receptor , microglia , chemokine , receptor , ccr1 , biology , cxcl5 , immune receptor , microbiology and biotechnology , immunology , inflammation , biochemistry
employed to calculate odds ratios (ORs), their 95% confidence intervals (CI) and corresponding p values, controlling for age and gender as covariates. In the logistic regression analysis for each SNP, we compared three different models of gene expression (codominant model, dominant model and recessive model). Results: SNP rs10466907 showed significant difference in the allele frequencies between AD and controls (p1⁄40.010). The genotype frequencies of rs10466907 showed significant association between AD and control groups [p1⁄40.003 in the co-dominant model; p1⁄40.01 in the dominant model]. No association was observed between genotype and BPSD severity as measured by the NPI. Conclusions: These results suggest that CACNA1C gene is a promising candidate gene in AD pathogenesis, and may represent a potential predisposing genetic factor for AD.