Premium
[P2–101]: CROSS STUDY INTEGRATIVE NETWORK ANALYSIS IDENTIFICATION OF AD DISEASE ETIOLOGY
Author(s) -
Logsdon Benjamin A.,
Perumal Thanneer M.,
Sieberts Solveig K.,
Omberg Larsson,
Mangravite Lara M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.750
Subject(s) - identification (biology) , computational biology , inference , disease , genome wide association study , gene co expression network , computer science , systems biology , transcriptome , set (abstract data type) , biology , gene , artificial intelligence , genetics , single nucleotide polymorphism , gene expression , medicine , pathology , botany , gene ontology , genotype , programming language
immunohistochemistry analyses using two previously reported TSPO antibodies in human post mortem brain sections. As reported previously, these antibodies stain macrophages, astrocytes and microglia in AD brains with more limited staining in non-AD cases. We used astrocyte and microglia specific markers to determine which cells were differentially stained between TREM2+ and TREM2AD cases and determine differences in cells adjacent to amyloid or Tau which stain for TSPO. Conclusions:The biomarker TSPO has been used extensively to explore immune activation in vivo in the brain. Levels are increased in AD, particularly associated with the emergence of abnormal Tau and neuronal cell loss. Our results will facilitate interpretation of future PET imaging in this group of patients using the TSPO tracers [C]-PK11195 or [C]-PBR28.