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[P2–100]: CLINICAL AND GENETIC STUDY OF A JAPANESE FAMILY WITH COMPLICATED HEREDITARY SPASTIC PARAPLEGIA AND ALZHEIMER'S DISEASE
Author(s) -
Montecchiani Celeste,
D'Onofrio Laura,
Mearini Marzia,
Gaudiello Fabrizio,
Miele Marialuisa,
Caltagirone Carlo,
Kawarai Toshitaka,
Orlacchio Antonio
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.749
Subject(s) - hereditary spastic paraplegia , medicine , dementia , disease , pediatrics , pes cavus , multiplex ligation dependent probe amplification , genetic heterogeneity , pathology , genetics , biology , phenotype , gene , exon , complication
immunohistochemistry analyses using two previously reported TSPO antibodies in human post mortem brain sections. As reported previously, these antibodies stain macrophages, astrocytes and microglia in AD brains with more limited staining in non-AD cases. We used astrocyte and microglia specific markers to determine which cells were differentially stained between TREM2+ and TREM2AD cases and determine differences in cells adjacent to amyloid or Tau which stain for TSPO. Conclusions:The biomarker TSPO has been used extensively to explore immune activation in vivo in the brain. Levels are increased in AD, particularly associated with the emergence of abnormal Tau and neuronal cell loss. Our results will facilitate interpretation of future PET imaging in this group of patients using the TSPO tracers [C]-PK11195 or [C]-PBR28.