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[P2–090]: ROLE OF SOLUBLE TNF IN DIET‐INDUCED PERIPHERAL AND CENTRAL INFLAMMATION IN A MOUSE MODEL OF ALZHEIMER's DISEASE
Author(s) -
Tansey Malu G.,
MacPherson Kathryn P.,
Eidson Lori N.,
Herrick Mary K.,
Elizabeth de Sousa Rodrigues Maria,
Oliver Danielle,
Kelly Sean D.,
Yang Yuan,
Chang Jianjun,
Sniffen Lindsey
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.739
Subject(s) - inflammation , immune system , microglia , tumor necrosis factor alpha , endocrinology , medicine , immunology , immunosenescence , blood–brain barrier , population , central nervous system , environmental health
large standardized dominance weights for IL-17a, interferongamma, IL-l2, and VEGF in CSF, as well IL-4 in serum. Conclusions: Inflammatory proteins have been widely documented in the AD brain. The results of the current study suggest that changes in BBB function resulting in altered permeability and transport are related to expression of specific inflammatory proteins, and that the shifting distribution of these proteins from serum to CSF in AD and MCI is correlated with more severe perturbations in BBB function.