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[P2–086]: EDUCATION AND PHYSICAL ACTIVITY IN RELATION TO FRAILTY AND WHOLE‐BRAIN STRUCTURAL HEALTH IN ALZHEIMER'S DISEASE, MILD COGNITIVE IMPAIRMENT, AND NORMAL AGING: RESULTS FROM THE AUSTRALIAN IMAGING, BIOMARKERS AND LIFESTYLE FLAGSHIP STUDY OF AGEING (AIBL)
Author(s) -
Song Xiaowei,
Dhindsa Navjot,
RaineySmith Stephanie R.,
Guo Hui,
Zeng An,
Brown Belinda M.,
Ames David,
Masters Colin L.,
Salvado Olivier,
Rowe Christopher C.,
D'Arcy Ryan C.N.,
Martins Ralph N.,
Rockwood Kenneth
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.735
Subject(s) - dementia , cognition , medicine , gerontology , atrophy , disease , cognitive decline , alzheimer's disease , psychology , clinical psychology , physical therapy , psychiatry
design enables identification of the peak fear tolerance therefore permitting to use the peak values for comparisons rather than sometimes having to use sometimes non-peak values for comparisons as those for the close or open arms in the EPM. Moreover, having the full spectrum of the animal’s responses also permits to standardize the animal’s fearful tolerance and to assign each animal a fearful tolerance index (FTI) score that is inversely correlated with the anxiogenic tendency. The FTI score enables across cohorts/studies comparisons without significant variations among different cohorts/studies, if they were performed under the same conditions using the same standard protocol. Conclusions: The EP task represents a significantly improved behavioral test for assessing rodent innate fear and anxiogenic tendency as compared to the golden standard task of EPM. The reason why the EP task is more sensitive than the EPM is that the former uses a full spectrum of fearful challenge to probe a continuous fearful responsiveness, the latter permits identifying the peak response for comparisons.