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[P2–045]: WEAK COMBINED MAGNETIC FIELDS INDUCE THE REDUCTION OF BRAIN AMYLOID‐β LEVEL IN AN ANIMAL MODEL OF SPORADIC ALZHEIMER'S DISEASE
Author(s) -
Novikov Vadim V.,
Bobkova Natalia V.,
Fesenko Evgeny E.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.693
Subject(s) - olfactory bulb , in vivo , latency (audio) , neuroscience , biology , medicine , central nervous system , computer science , microbiology and biotechnology , telecommunications
Background:In this work the effect of the weak combined MFs was studied in vivo in bulbectomized (BE) mice. Previously we showed that ablation of olfactory bulbs induced the behavioral, morphological, immunological, and biochemical signs similar to AD in mice, rats, and guinea pigs. BE animals demonstrated pronounced impairment of the spatial memory, an increase in the b-A level in the brain, pathology in the acetylcholinergic system, and the loss of neurons in the brain structures responsible for memory. Methods: The control was sham-operated (SO) mice, subjected to the same procedures except the olfactory bulb ablation. The BE and SO animals were exposed to the weak combined MFs five weeks after bulbectomy. A setup for generating a MF consisted of two pairs of coaxial Helmhollz coils oriented along the geomagnetic field vector. A direct current was supplied to one of the pairs of coils to generate a constant component of MF with induction of 42 mcT. An alternating current signal produced by a programmable sinusoidal current generator was fed to other pair of coils to create a variable component of MF with induction of amplitude of 80 nT. The current signal was the sum of two signals with frequencies of 4.38 and 4.88 Hz. Results: It indicates the decreased ability to study spatial skills in the BE animals. The exposure to the MF decreased the average latency in the SO animals only. The data suggest that the MF does not affect the learning rate in the BEmice and that the SO animals have an increased sensitivity to the MF. One month after exposure to the MF the SO animals demonstrated an increased latency on the first day of retraining. The sensitive DOT analysis revealed that the b-A level in the extracts of the BE animals was more than five times higher in comparison to SO mice. The exposure to the MF induced the reliably decrease the b-A level almost three fold, but it was higher then in SO mice. Conclusions:Thus, the data suggest that MFs can be applied for preventive purposes in a group of risk of AD.