Premium
[P2–039]: ISO‐α‐ACIDS, BITTER COMPONENTS OF BEER, PREVENT CEREBRAL INFLAMMATION AND COGNITIVE DECLINE IN A MOUSE MODEL OF ALZHEIMER's DISEASE
Author(s) -
Ano Yasuhisa,
Dohata Atsushi,
Ayabe Tatsuhiro,
Uchida Kazuyuki,
Takashima Akihiko,
Kondo Keiji,
Nakayama Hiroyuki
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.687
Subject(s) - microglia , synaptophysin , lipopolysaccharide , cd36 , inflammation , pharmacology , scavenger receptor , stimulation , integrin alpha m , chemistry , synaptic pruning , tumor necrosis factor alpha , trem2 , medicine , immune system , immunology , endocrinology , receptor , biochemistry , immunohistochemistry , cholesterol , lipoprotein
iso-a-acids, hop-derived bitter components of beer, prevent dietinduced obesity in mice and humans. However, the effects of isoa-acids on cognitive functions via obesity prevention have not been elucidated. In the present study, we investigated the effects of iso-a-acids on cognitive decline accompanied with obesity using obese mice induced with high fat diet (HFD). Methods:Five-weekold C57BL/6J male mice were fed with normal diet (ND), 60% HFD or 60% HFD containing 0.05% (w/w) iso-a-acids (HFDIAA) for 8 weeks. After 7 weeks of HFD-feeding, cognitive function was evaluated by object recognition test (ORT) and object location test (OLT). After 8 weeks of feeding, each tissue was collected after sacrifice and the plasma composition was analyzed by biochemistry autoanalyzer. The amounts of cytokines and chemokines in the brain were quantified by multiplex assay. Results: Body weight gain in HFD-IAA-fed mice was significantly lower than that in HFD-fed mice after 14 days of HFD-feeding. The weight of epididymal fat and the levels of blood glucose and triglyceride in HFD-IAA-fed mice were also significantly lower than those in HFD-fed mice. As a result of ORT and OLT, the approaching time to novel object and location in HFD-fed mice exhibited a significant reduction compared with those in ND-fed mice, whereas the time in the HFD-IAA-fed mice were significantly longer than those in HFD-fed mice. These results suggest that iso-a-acids improve obesity-induced memory impairment. The weight of hippocampus in HFD-fed mice was significantly decreased compared with ND-fed mice, and the significant reduction was not observed in HFD-IAA-fed mice. Furthermore, the amounts of TNF-a and IL-1b in hippocampus in HFD-fed mice were significantly increased compared with ND-fed mice, and those in HFD-IAA-fed micewere significantly decreased compared with HFD-fed mice. Conclusions: In this study, we elucidated that iso-a-acids, the bitter components of beer, prevent cognitive decline accompanied with obesity. Iso-a-acids might be beneficial for the risk of dementia increased by obesity and metabolic syndrome.