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[P2–018]: MANAGING POTENTIAL BLEEDING COMPLICATIONS ASSOCIATED WITH HERBAL SUPPLEMENTS, ANTIPLATELET AND ANTICOAGULANT MEDICATIONS IN PARKINSON'S AND ALZHEIMER'S
Author(s) -
Barber Elizabeth K.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.666
Subject(s) - medicine , anticoagulant , warfarin , aspirin , coenzyme q10 , apixaban , intensive care medicine , resveratrol , clopidogrel , stroke (engine) , rivaroxaban , atrial fibrillation , surgery , pharmacology , mechanical engineering , engineering
Background:Anticoagulant and antiplatelet and herbal medicines known to alter bleeding are often taken by Parkinson’s and Alzheimer’s patients, often to reduce the risk of thromboembolic events, discontinued before surgery. Little has been written about the coagulant and anticoagulant properties of some supplements with potential benefit for both diseases, such as resveratrol with red wine polyphenols and CoEnzyme Q10. Anticoagulation is a particular risk for patients at risk of falling and thus the benefits and risks of both coagulants and anticoagulants will be assessed. Methods: A Parkinson’s patient with later Alzheimer’s changes who suffered a fall on warfarin in response to a pulmonary embolism, followed by low-dose aspirin and resveratrol was assessed for potential bleeding complications, such as surface hematomas. Previously unstudied resveratrol showed symptomatic benefits while also providing anticoagulation benefits, balanced by the coagulation properties of CoEnzyme Q10. A chart of the known anticoagulant vs. coagulant properties of relevant anticoagulant, antiplatelet and herbal medicines was prepared. The degree to which medical schools or fellowship programs teach about relevant herbal medicines/dietary supplements was assessed. Results:Some anticoagulants appear to magnify each other’s effects in some patients, such as resveratrol and aspirin and patients should be informed of the signs of excessive bleeding on certain supplements, especially over a long period. Conclusions:Although the benefits of certain anticoagulants for Parkinson’s and Alzheimer’s outweigh the risks, medical and patient education should add a module on the anticoagulant and coagulant benefits of relevant prescription and herbal medicines to minimize patients’ risk of suffering bleeding complications.