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[P1–588]: SLEEP‐DISORDERED BREATHING, COGNITIVE FUNCTION AND RISK OF COGNITIVE IMPAIRMENT: A SYSTEMATIC REVIEW AND META‐ANALYSIS
Author(s) -
Leng Yue,
McEvoy Claire T.,
Allen Isabel,
Yaffe Kristine
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.604
Subject(s) - meta analysis , funnel plot , publication bias , medicine , cognition , prospective cohort study , population , clinical psychology , psychiatry , environmental health
of benzodiazepineswas associatedwith an increased risk of dementia (OR1⁄41.36, 95%CI 1.09-1.70), as was former (OR1⁄41.63, 95%CI 1.51-1.76) but not current use (OR1⁄41.64, 95%CI 0.83-3.27). Studies with no lag time had an increased risk estimate (OR1⁄41.53, 95%CI 1.14-2.04) compared to thosewhich introduced a lag time to eliminate protopathic bias (OR1⁄41.16, 95%CI 1.03-1.31), but importantly the latter resultwas still statistically significant. The association persisted in studies with a 5-year lag time. Conclusions:Benzodiazepine use increases the risk of dementia by about 16%, after corrections to eliminate protopathic bias. Given the high prevalence of benzodiazepine use, this increase in risk would translate into a large number of real cases and hence benzodiazepine prescribing practices should be reviewed.