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[P1–580]: INCREASED PREVALENCE OF NON‐THYROID AUTOIMMUNE DISEASE IN PATIENTS WITH FAMILIAL FRONTOTEMPORAL DEMENTIA ASSOCIATED WITH PROGRANULIN MUTATIONS
Author(s) -
Woollacott Ione OC.,
Dick Katrina M.,
Marshall Charles R.,
Russell Lucy L.,
Warren Jason D.,
Rohrer Jonathan D.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.596
Subject(s) - c9orf72 , frontotemporal dementia , medicine , mutation , disease , thyroid , thyroid disease , oncology , dementia , gastroenterology , genetics , biology , gene
consent materials, ii) survey and workshops to estimate likely brain donation uptake, iii) MRC UK Brain Bank Network collaboration to identify and evaluate scientific value of brain banking strategies in relation to standards for collection, classification and storage of brain tissue, sample access and ethical approaches. Results:Relatively few cohorts currently offer brain donation and adaptation of existing protocols is necessary for inclusion of brain donation (e.g. inclusion of consultees for participants who lose capacity, nominated representatives to confirm donation after death). Criteria for identifying the most informative cohorts were developed and consent forms and related materials are now available to cohorts. Workshops and a brain donation survey indicated high levels of participant support for brain donation (44%). An International Brain Banking Advisory Panel has been established in order to advise and provide comment on developing a brain donation programme within DPUK. Conclusions: Brain donation, as the final contribution, by participants in longitudinal cohort studies, is a promising solution for increasing the collection of scientifically informative brains. Consent materials and processes have been developed and are available for selective brain donation within cohorts. Strategies are emerging to ensure careful, informed and affordable approaches for collection, curation and the most informative science from a brain donation programme.