[P1–567]: PREVALENCE OF DEMENTIA BY STATE AND LEVEL OF MARGINALIZATION IN MEXICO

8.92]) per 1,000 person years in the T2DM and non-T2DM cohorts, respectively. Individuals with cancer had a 48 % and 26 % reduction risk of LOD compared to those without cancer in the T2DM and non-T2DM cohorts, respectively. Cancer patients had a decreased risk for LOD [HR1⁄40.67, 95 % CI (0.66-0.68) p<0.01] in the T2DM and [HR1⁄40.50, 95 % CI (0.47-0.53) p< 0.01] non-T2DM cohorts. This inverse association persisted when the outcome of interest was examined with specific forms of cancers. For example, there was a decreased risk for LOD in individuals with bladder cancer in both T2DM [HR1⁄40.52, 95 % CI (0.43-0.63) p<0.01] and non-T2DM cohorts [HR1⁄40.77, 95 % CI (0.72-0.83) p<0.01]. Conclusions: Our results suggest an inverse association between several forms of cancer and LOD independent of T2DM status. In an ageing population, the understanding of biological links between comorbid conditions is imperative to improve our knowledge of biological pathways and mechanisms of common diseases. If further validated our findings may help inform more refined preventative strategies and approaches.