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[P1–506]: EFFECTS OF EDUCATION AND AGE ON PERFORMANCE OF THE MEXICAN VERSION OF THE CERAD‐COL
Author(s) -
Reyes Angélica Zuno,
Matute Esmeralda,
Dueñas Lourdes Ramírez
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.522
Subject(s) - gerontology , medicine , population , age groups , neuropsychology , affect (linguistics) , test (biology) , demography , psychology , cognition , psychiatry , environmental health , paleontology , communication , sociology , biology
function [Frontal Assessment Battery (FAB) and animal naming fluency].[Table 1] Having AF was associated with an odds ratio of 2.17 for developing PSCI (95% CI: 1.03 – 4.58; p1⁄40.041)] after adjusting for age, education, hypertension, large cortical and noncortical infarcts, WMH, and intracranial stenosis. When comparing subjects in the four conditions, AF+LCI subjects scored worse in MMSE, MoCA, and FAB than LCI Only and Nil subjects. AF Only subjects scored worse in 10-word immediate recall than Nil subjects. [Figure 1]. Conclusions:AF is a significant risk factor for PSCI, and this effect is independent of acute infarct characteristics. The profile of PSCI in subjects with AF is characterized by deficits in episodic memory and executive function. Pathophysiological links between AF and PSCI, likely includes mechanisms other than infarcts such as cerebral hypoperfusion and neuroinflammation, may help to explain the observed impairments in these specific cognitive subdomains.