Premium
[P1–503]: MODIFIABLE RISK FACTORS MODERATE THE RELATIONSHIP BETWEEN BETA‐AMYLOID AND LONGITUDINAL COGNITIVE TRAJECTORIES IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION STUDY
Author(s) -
Clark Lindsay R.,
Koscik Rebecca L.,
Berman Sara Elizabeth,
Carlsson Cynthia M.,
Norton Derek L.,
Bendlin Barbara B.,
Asthana Sanjay,
Johnson Sterling C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.519
Subject(s) - longitudinal study , cognitive decline , medicine , amyloid (mycology) , amyloid beta , cognition , psychology , effects of sleep deprivation on cognitive performance , obesity , risk factor , disease , gerontology , dementia , oncology , psychiatry , pathology
domains declined in non-diabetics. In cognitively normal group, diabetics had a slightly accelerated rate of decline over time in language and executive function domains. In aMCI group, diabetics had significantly slower deterioration in attention and language domains. In naMCI group, diabetics had significantly slower deterioration in executive function domain. Conclusions: Diabetes may be associated with lower cognitive performance, primarily in non-memory domains. However, it is not associated with continued worsening, suggesting a static deficit with minimal memory involvement. This suggests that diabetes may contribution more to a vascular profile of cognitive impairment and not to that typical of AD. CESD >1⁄4 16 at baseline) Obesity (n, % high risk: women waist >88 cm, men waist >102 cm) 82 (39%)