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[P1–491]: DO SEMANTIC CLUSTERING DEFICITS UNDERPIN LONG‐TERM MEMORY BINDING IMPAIRMENTS IN PRODROMAL AD?
Author(s) -
Calia Clara,
Backhouse Ellen V.,
Pattan Vivek,
Clafferty Robert,
Starr John M.,
Della Sala Sergio,
Parra Mario Alfredo
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.507
Subject(s) - psychology , neuropsychology , audiology , free recall , dementia , episodic memory , cognition , recall , cognitive psychology , medicine , neuroscience , disease
greater cost than their e3 counterparts. This pattern was reversed in young adulthood, with e4s tending towards a smaller cost. Across both genotypes, cost decreased with increasing WM load suggesting everybody was being forced to switch to a more focal strategy. Under WM load the e3s performed more like the e4s, which may suggest mid-age e4s were already working harder in the no load block. This differencewas supported by subjective report measures. Conclusions:Age-associated increases in prospective memory cost in e4 carriers are consistent with reduced processing in this group by mid-adulthood. Additionally, we identified age and genotype differences in the use of strategies to support PM performance. Further research is needed to understand the mechanisms of these early genotype differences in PM.