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[P1–458]: DOWN SYNDROME: AGE‐DEPENDENCE OF PIB BINDING IN POSTMORTEM FRONTAL CORTEX ACROSS THE LIFESPAN
Author(s) -
Head Elizabeth,
LeVine Harry,
Spielmann H. Peter,
Matveev Sergey,
Cauvi Francesca Macchiavello,
Murphy Paul,
Beckett Tina,
McCarty Katie,
Lott Ira T.,
Doran Eric,
Schmitt Frederick A.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.474
Subject(s) - neuropathology , pittsburgh compound b , cerebral amyloid angiopathy , pathology , postmortem studies , temporal cortex , dementia , alzheimer's disease , in vivo , cortex (anatomy) , autopsy , medicine , neuroscience , psychology , biology , disease , genetics
alcoholism, Parkinson’s disease, subdural hematoma, and normal pressure hydrocephalus. We measured Ab and cortical thickness in prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate/precuneus, and motor-specific (i.e., PiB-PET averaged across the precentral gyrus, postcentral gyrus, Rolandic operculum, supplementary motor area) ROIs. Gait parameters (gait speed, cadence, stride length, double support time, and covariance (CoV) stance time) were assessed with GAITRite . We used multivariable adjusted two-level structural equation modeling to investigate the association between PiB-PET SUVR, cortical thickness, and gait. Results: Among all participants, greater PiB-PET SUVR in all regions was associated with significant declines in gait function including declining cadence, increasing double support time, and increasing CoV stance time. Further, higher PiBPET SUVR in the prefrontal, orbitofrontal, and temporal ROIs was associated with declining gait speed (all p’s<0.05). In sexstratified analyses, the findings were most robust and only significant among the 206 women. Notably, none of these associations were mediated by cortical thickness in the corresponding ROIs. Conclusions:Greater PiB-PETSUVRwas associatedwithworsening gait across multiple measures. These findings were only significant among women in sex-stratified analyses. Importantly, cortical thickness was not a mediator on this pathway. These findings suggest that the effect of cerebral Ab deposition on gait could be independent of neurodegeneration in the corresponding area of Ab deposition.