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[P1–455]: REGIONAL WHITE MATTER HYPERINTENSITY CHANGES PREDICT COGNITIVE DECLINE IN MILD COGNITIVE IMPAIRMENT OF SUBCORTICAL VASCULAR TYPE: A THREE‐YEAR FOLLOW‐UP STUDY
Author(s) -
Jang Young Kyoung,
Lee Jong Min,
Kim Hee Jin,
Seo Sang Won
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.471
Subject(s) - hyperintensity , cognitive decline , neuropsychology , cognition , cardiology , brain size , psychology , white matter , leukoaraiosis , magnetic resonance imaging , audiology , medicine , neuroscience , dementia , disease , radiology
Asan Medical Center. Cerebellar gray matter was used as a reference region and we measured regional tau standardized uptake value ratio (SUVR). We used freeSurfer-derived ROIs. Results: In logistic regression, amyloid positivity was not correlated with education years significantly. However, education years were positively correlated with [F]THK-5351 SUVR in the left lingual and left superior temporal region (p 1⁄4 0.024 and 0.029, respectively).Conclusions:Our results show that ADwith higher education had suffered more pronounced tau burdens in specific parts of the brain than ADwith lower education, which may be related to cognitive reserve theory.