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[P1–454]: POSITIVE ASSOCIATION BETWEEN EDUCATION AND THK‐5351 UPTAKES IN PATIENTS WITH ALZHEIMER's DISEASE
Author(s) -
Kim Yeshin,
Jang Hyemin,
Jang Young Kyoung,
Kim Ko Woon,
San Lee Jin,
Park Yuhyun,
Park Seongbeom,
Kim Sung Tae,
Oh Seung Jun,
Roh Jee Hoon,
Oh Minyoung,
Kim Jae Seung,
Kim Hee Jin,
Na Duk L.,
Seo Sang Won
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.470
Subject(s) - cognitive reserve , logistic regression , medicine , cognitive impairment , alzheimer's disease , cognition , psychology , gerontology , disease , nuclear medicine , psychiatry
synergistically interact with the regional levels of network dysfunction to determine subsequent clinical progression to dementia. Notably, the same results in the posterior DMN of the transgenic amyloid-b rats, which do not form neurofibrillary tangles, supported this model as an independent mechanism of cognitive deterioration (Fig.2). Conclusions: These findings highlight a model where a widespread amyloid-b aggregation determines the vulnerability of the well conserved – in mammals – DMN, whereas the synergism between this vulnerability and the regional concentrations of amyloid-b aggregates determines dementia symptoms.