[P1–445]: FUNCTIONAL NETWORK FOR BASIC, INSTRUMENTAL AND ADVANCED IADL IN ALZHEIMER'S DISEASES: THE TECHNOLOGY‐ACTIVITIES OF DAILY LIVING QUESTIONNAIRE

(74.969.3) were collected as part of the Australian Imaging Biomarkers and Lifestyle (AIBL) study. Seven to eight year longitudinal data, acquired at 18-month intervals, included T1W-MRI and C PiB-PET. Cross sectional data at baseline included GRE-MRI scans processed for QSM. Aß-amyloid PET, QSM, and volumetric images were normalized with cerebellar gray matter, middle frontal white matter, and intracranial volume respectively. Participants were classified as being Aß+ when above 1.5 SUVR. Region of interest analysis was conducted using a mixed effect model to investigate the association of hippocampal volume with baseline QSMsusceptibility, controlling for age, gender, APOE ε4 carrier status and SUVR (continuous variable). Results: 41 CN were classified as Aßand 15 as Aß+ while all AD subjects were Aß+. A significant negative association was found between volume and QSM-susceptibility in the hippocampus for Aß+ CN (b1⁄4‒4.2261.3, p 1⁄40.002) and AD (ß1⁄4‒3.5761.5, p1⁄4 0.019), while no significant trend was found for AßCN (Fig. 1). Conclusions: The results suggest that QSM in combination with Aß-amyloid PET imaging could be a valuable tool to predict hippocampal atrophy across the AD spectrum.