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[P1–444]: QUANTITATIVE SUSCEPTIBILITY MAPPING OF THE HIPPOCAMPUS PREDICTS HIPPOCAMPAL ATROPHY IN Aβ+ ELDERLY CONTROLS AND ALZHEIMER's DISEASE PATIENTS
Author(s) -
Fazlollahi Amir,
Ayton Scott,
Diouf Ibrahima,
Bourgeat Pierrick,
Raniga Parnesh,
Dore Vincent,
Ng Amanda,
Fripp Jurgen,
Ames David,
Masters Colin L.,
Rowe Christopher C.,
Villemagne Victor LL.,
Bush Ashley I.,
Salvado Olivier
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.460
Subject(s) - quantitative susceptibility mapping , hippocampal formation , hippocampus , atrophy , white matter , medicine , magnetic resonance imaging , nuclear medicine , pathology , radiology
ures (A)-(D) show the progression pattern of each of the four subtypes estimated by SuStaln. Each progression pattern consists of a sequence in which regional brain volumes in mutation carriers (affected and unaffected) reach different z-scores relative to non-carriers. The cumulative probability each region has reached a particular z-score is shown for different stages along the progression; the cumulative probability of a region going from a z-score of 0-sigma to 1-sigma ranges from 0 in white to 1 in red, the cumulative probability of a region going from a z-score of 1-sigma to 2-sigma ranges from 0 in red to 1 in magenta, and the cumulative probability of a region going from a z-score of 2-sigma to 3-sigma ranges from 0 in magenta to 1 in blue. The circle labelled ’A’ indicates the asymmetry of the atrophy pattern (absolute value of the difference in volume between the left and right hemispheres divided by the total volume of the left and right hemispheres) at each stage for each subtype. CVS is the model crossvalidation similarity: the average similarity of the subtype progression patterns across cross-validation folds, measured using the Bhattacharyya coefficient. The CVS ranges from 0 (no similarity) to 1 (maximum similarity). Poster Presentations: Sunday, July 16, 2017 P454