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[P1–437]: PRESYMPTOMATIC WHITE MATTER INTEGRITY LOSS IN FAMILIAL FRONTOTEMPORAL DEMENTIA IN THE GENETIC FRONTOTEMPORAL DEMENTIA INITIATIVE (GENFI) COHORT: A MULTI‐CENTRE, CROSS‐SECTIONAL, DIFFUSION TENSOR IMAGING STUDY
Author(s) -
Jiskoot Lize C.,
Bocchetta Martina,
Papma Janne M.,
Nicholas Jennifer M.,
Cash David M.,
Modat Marc,
Borroni Barbara,
Galimberti Daniela,
Masellis Mario,
Tartaglia Maria Carmela,
Rowe James B.,
Graff Caroline,
Tagliavini Fabrizio,
Frisoni Giovanni B.,
Laforce Robert,
Finger Elizabeth,
Mendonca Alexandre,
Sorbi Sandro,
Rohrer Jonathan D.,
Swieten John C.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.453
Subject(s) - corpus callosum , frontotemporal dementia , fractional anisotropy , internal capsule , splenium , uncinate fasciculus , c9orf72 , white matter , diffusion mri , medicine , neuroscience , pathology , psychology , dementia , radiology , magnetic resonance imaging , disease
threshold of p1⁄40.05, uncorrected. Resulting clusters were considered statistically significant if the family-wise error corrected pvalue of the cluster was 0.05 or less. Results:BGL ranged between 59 and 149 mg/dl (98616 mg/dl). There was a significant cluster of negative correlation between scaled FDG uptake and BGL comprising precuneus and bilateral parieto-occipital cortex (cluster volume 123 ml, p1⁄40.020). The cluster did not include the posterior cingulate. Positive correlation was detected in a large cluster of white matter in the centrum semiovale (245 ml, p<0.0005). A piecewise linear broken stickmodel used to fit mean FDG uptake in the cluster of negative correlation as a function of BGL identified a breaking point at 94 mg/dl. Unexpectedly, the decline of scaled FDG uptake in this cluster was steeper below the breaking point than above. The broken stick provided a better fit of the data than a straight line (Akaike Information Criterion). Conclusions: These findings confirm that even within an ‘acceptable’ range of BGL ( 150mg/dl) increased blood glucose is associated with a relative reduction of FDG uptake in the cortex compared to white matter. BGL-related reduction of metabolism is most pronounced in posterior brain regions including the precuneus (more than posterior cingulate) and parieto-occipital (rather than parieto-temporal) cortex. Thus, the BGL-associated pattern overlaps with, but is not identical to the pattern of cortical hypometabolism typically observed in AD.