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[P1–424]: DETECTION OF SMALL INFARCTS IN THE CAUDATE NUCLEUS ON 7 TESLA MRI: THE SMART‐MR STUDY
Author(s) -
Ghaznawi Rashid,
Geerlings Mirjam I.,
Hendrikse Jeroen,
Bresser Jeroen,
Witkamp Theo,
Zwartbol Maarten,
Graaf Yolanda
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.440
Subject(s) - medicine , caudate nucleus , intraclass correlation , magnetic resonance imaging , radiology , nuclear medicine , prospective cohort study , pathology , clinical psychology , psychometrics
N 869 473 79 53 (67.1) 26 (32.9) 27 14 (51.9) 13 (48.1) Age, y 65.4 (9.0) 73.0 (9.4) < 0.001 69.7 (8.8) 69.1 (9.0) 70.9 (8.6) 0.410 70.4 (7.6) 72.0 (6.6) 68.8 (8.4) 0.276 Age of onset, year 68.5 (10.7) 67.1 (8.6) 66.3(8.6) 68.5 (8.4) 0.308 67.2 (7.7) 68.0 (6.9) 66.4 (8.7) 0.595 Women 599 (68.9) 307 (64.9) 0.133 46 (58.2) 29 (54.7) 17 (65.4) 0.366 18 (66.7) 10 (71.4) 8 (61.5) 0.695 Education, y 11.7 (4.9) 9.4 (5.3) < 0.001 12.1 (4.6) 12.1 (4.4) 12.1 (5.0) 0.971 10.3 (5.1) 9.5 (6.2) 11.2 (3.6) 0.392 APOE ε4 present* 135 (22.8) 180 (55.6) < 0.001 29 (39.2) 15 (29.4) 14 (60.9) 0.010 4 (66.7) 2 (50.0) 2 (100.0) 0.467 MMSE 28.5 (2.0) 18.2 (5.5) < 0.001 26.4 (2.4) 27.0 (1.9) 25.4 (3.0) 0.015 21.4 (3.1) 21.1 (3.0) 21.7 (3.3) 0.616 Vascular risk factors DM 178 (20.5) 112 (23.7) 0.174 35 (44.3) 26 (49.1) 9 (34.6) 0.225 6 (22.2) 5 (35.7) 1 (7.7) 0.165 Hypertension 260 (29.9) 206 (43.6) < 0.001 31 (39.2) 21 (39.6) 10 (38.5) 0.921 14 (51.9) 8 (57.1) 6 (46.2) 0.568 Hyperlipidemia 238 (27.4) 90 (19.0) 0.001 25 (31.6) 19 (35.8) 6 (23.1) 0.251 6 (22.2) 3 (21.4) 3 (23.1) 1.000 History of IHD 110 (12.7) 43 (9.1) 0.049 17 (21.5) 9 (17.0) 8 (30.8) 0.161 2 (7.4) 1 (7.1) 1 (7.7) 1.000 History of stroke 32 (3.7) 26 (5.5) 0.118 2 (2.5) 2 (3.8) 0 (0.0) 0.316 1 (3.7) 1 (7.1) 0 (0.0) -