[P1–412]: GENOME‐WIDE ASSOCIATION STUDY OF A MULTIMODAL IMAGING BIOMARKER IN THE ADNI COHORT | Zendy

Scelsi Marzia Antonella | Zendy; Lorenzi Marco | Zendy; Schott Jon M. | Zendy; Ourselin Sebastien | Zendy; Altmann Andre | Zendy

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[P1–412]: GENOME‐WIDE ASSOCIATION STUDY OF A MULTIMODAL IMAGING BIOMARKER IN THE ADNI COHORT

Author(s) -

Scelsi Marzia Antonella,

Lorenzi Marco,

Schott Jon M.,

Ourselin Sebastien,

Altmann Andre

Publication year - 2017

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2017.06.428

Subject(s) - genome wide association study , neuroimaging , alzheimer's disease neuroimaging initiative , genetic association , single nucleotide polymorphism , population , biomarker , biology , oncology , disease , genetics , medicine , neuroscience , alzheimer's disease , genotype , gene , environmental health

Within pair differences in vascular risk factors (summarized in the Framingham risk score) were regressed on the within pair differences in total WMH. A significant relation suggests a direct relation between vascular risk factors and WMH, by factoring out the possibility of confounding by genetic factors. Figure 1. Long-term progression curves for two AD biomarkers. Left, florbetapir PET SUVR; right, bilateral hippocampal volume. Poster Presentations: Sunday, July 16, 2017 P434

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