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[P1–412]: GENOME‐WIDE ASSOCIATION STUDY OF A MULTIMODAL IMAGING BIOMARKER IN THE ADNI COHORT
Author(s) -
Scelsi Marzia Antonella,
Lorenzi Marco,
Schott Jon M.,
Ourselin Sebastien,
Altmann Andre
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.428
Subject(s) - genome wide association study , neuroimaging , alzheimer's disease neuroimaging initiative , genetic association , single nucleotide polymorphism , population , biomarker , biology , oncology , disease , genetics , medicine , neuroscience , alzheimer's disease , genotype , gene , environmental health
Within pair differences in vascular risk factors (summarized in the Framingham risk score) were regressed on the within pair differences in total WMH. A significant relation suggests a direct relation between vascular risk factors and WMH, by factoring out the possibility of confounding by genetic factors. Figure 1. Long-term progression curves for two AD biomarkers. Left, florbetapir PET SUVR; right, bilateral hippocampal volume. Poster Presentations: Sunday, July 16, 2017 P434