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[P1–397]: A PROSPECTIVE OBSERVATIONAL STUDY INVESTIGATING CLINICAL RESPONSE TO CHOLINESTERASE INHIBITORS AND ASSOCIATION WITH CEREBRAL PERFUSION
Author(s) -
Compag Jordana,
Mutsaerts Henri JMM.,
Freedman Morris,
Li Julian,
Kleiner Galit,
Lee Joyce,
Kennedy James,
Chen Robert,
TangWai David F.,
Lang Anthony E.,
Herrmann Nathan,
Black Sandra E.,
Masellis Mario
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.413
Subject(s) - dementia with lewy bodies , dementia , medicine , rivastigmine , psychology , observational study , cognition , lewy body , donepezil , psychiatry , disease
blood at the border of the temporal and parietal regions due to the increased amount of blood from arteriovenous shunts; increased looping of distal intracranial arterial branches. Control Group patients with other cerebral neurodegenerative lesions did not have the same complex of the changes in the vascular and microcirculatory system.Conclusions:The data received prove that CSVD during AD have a complex of specific features, which we named dyscirculatory angiopathy of Alzheimer’s type (DAAT). Other neurodegenerative diseases have no complex of such CSVD changes, as they are characteristic only of AD. DAAT appears many decades before the primary clinical AD symptoms. Direct descendants of patients with AD acquire DAAT in their childhood; it is also characteristic for patients with AD pre-clinical stage. DAAT progression leads to disorders in the metabolism of abnormal proteins causing their accumulation in cerebral tissues and the vascular wall, which inhibits cerebral microcirculation even more leading to atrophic changes in the cerebral tissue and AD progression.