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[P1–381]: MEASUREMENT OF PATHOLOGICAL AMYLOID IN ROUTINE CLINICAL ASSESSMENT: THE CLINICAL IMPACT OF VISUAL [ 18 F]FLUTEMETAMOL PET AND CSF ANALYSIS
Author(s) -
Bogdanovic Nenad,
Farrar Gill,
Fantoni Enrico R.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.397
Subject(s) - concordance , medicine , neurology , amyloid (mycology) , dementia , pathology , positron emission tomography , nuclear medicine , psychology , disease , psychiatry
Some sulcal regions show expansion with tight high convexity and others contraction. Data from regions with AUROCS in excess of 0.7 were used to build an LDA model with an AUROC of 0.94 (Figure 3). Conclusions:An entirely automated method can be used to predict classification of tight high convexity. By combining both contracted and expanded CSF spaces, the LDA classifier captures many of the patients with DESH, an important radiological feature of iNPH, and is consistent with the hypothesis that tight high convexity is neither atrophy nor inflammation but a shifting of tissue.