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[P1–371]: MULTIPLE‐STIMULUS HEMODYNAMIC RESPONSE FUNCTION IN PATIENTS WITH PRODROMAL ALZHEIMER's DISEASE
Author(s) -
Kotliar Konstantin,
Ghaderi Aydin,
Suryoputri Nathania,
Linder Peter,
Göttler Jens,
Sorg Christian,
Grimmer Timo
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.387
Subject(s) - haemodynamic response , dementia , default mode network , stimulus (psychology) , voxel , psychology , medicine , alzheimer's disease , neuroscience , hemodynamics , audiology , functional magnetic resonance imaging , cardiology , disease , radiology , cognitive psychology , heart rate , blood pressure
the stimulation site (lIPL: p1⁄40.023; PMC: p<0.001 and rIPL: p<0.001). Amongst elders, greater functional responses to rTMS in mPFC regions were positively related to better baseline memory performance (r1⁄40.686; p1⁄40.014). Conclusions:Our results reveal that resting-state connectivity responses to iTBS within DMN are modulated by age. Advancing age appears to attenuate functional connectivity involving long-range connections, while it increases local connectivity. This pattern of effects is coherent with observational neuroimaging studies (SalaLlonch et al., NeurobiolAging.2014.Oct;35(10):2193-202). Furthermore, ‘young-like’ responses to rTMS appear to be characteristic of elders with better preserved cognitive function. Further studies might investigate if particular connectivity responses to TMS are distinctive of elders at risk or in preclinical stages of dementia.