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[P1–367]: CLINICAL AND IMAGING CHARACTERISTICS OF ATYPICAL PARKINSONISM: CASE SERIES
Author(s) -
EscobedoMartínez Jorge Alberto,
Bayliss Leo,
AcostaCastillo Gilberto Isaac,
SosaOrtiz Ana Luisa
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.383
Subject(s) - progressive supranuclear palsy , dementia with lewy bodies , corticobasal degeneration , parkinsonism , psychology , parkinson's disease , medicine , hyperintensity , neurology , pathology , cardiology , atrophy , dementia , neuroscience , audiology , magnetic resonance imaging , radiology , disease
Background:Weight loss might be a risk factor for mild cognitive impairment (MCI) and dementia. We assessed its impact on cognitive decline and its association with Alzheimer’s Disease (AD) biomarkers in healthy elderly (HC). Methods: Longitudinal observational study of HC (n1⁄4377) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We evaluated the progression to MCI or dementia, the baseline cerebrospinal fluid (CSF) core AD biomarkers profile, amyloid PET uptake (AV45) and baseline and 2-year longitudinal brain atrophy patterns according to weight trajectories (relative weight loss 5%). Results:After a mean followup of 46.8627.8 months 74 individuals (19.6%) progressed toMCI or dementia. Weight loss (HR: 1.759, CI95%: 1.057 to 2.925) predicted progression to MCI or dementia and was associated to a higher total tau/Aß42 ratio (p1⁄40.045) and increased AV45 uptake (p1⁄40.016). 132 HC had 3T MRI and CSF (tau and Aß42) available and 101 HC had 2 years MRI follow-up. Subjects with significant weight loss (WL-g) presented decreased cortical thickness at baseline in temporal regions and an accelerated 2-year cortical thinning in frontal regions in both hemispheres compared with subjects without weight loss (nWL-g) even after excluding those HC that progressed to MCI or dementia in the follow-up. Conclusions: Late-life weight loss is associated with increased AD biomarker burden, decreased CTh and accelerated atrophy rates in AD vulnerable areas. Weight loss might thus be a non-cognitive sign of preclinical AD. The mechanisms involved in this association deserve further investigation.