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[P1–360]: CEREBRAL 18F‐FLUORODEOXYGLUCOSE‐POSITRON EMISSION TOMOGRAPHY IN PROLONGED DELIRIUM
Author(s) -
Pion Caroline Malo,
Filion Josée,
Nehme Jessica,
Desmarais Philippe,
Masson Hélène,
Bruneau MarieAndrée,
Soucy JeanPaul
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.376
Subject(s) - delirium , dementia , medicine , neuroimaging , positron emission tomography , disease , pediatrics , psychiatry , radiology
comparisons (alpha1⁄40.05). Assessing the concordance of the interaction effects with Alzheimer’s dementia, we sampled spatial correlations of the significant effect maps over an empirical spatial map distribution, obtaining a concordance value (between -1 and 1), and a non-parametric p-value. Results:Shape of all 7 subcortical regions differed significantly between AD and control subjects. The left caudate head, thalamus, pallidum, nucleus accumbens expanded significantly with higher UPDRS. Dementia and Parkinsonism had a significant multiplicative effect on left caudate and left putamen, over and above additive effects (see figures for all FDR critical p-values). AD and symptom interaction maps had a significant concordance (p1⁄40.0019, C1⁄40.078). Conclusions: Our findings are a step toward identifying interactions between PD and AD pathology. The caudate head appears to be the most robust morphometric marker of symptom interaction.